Cryptococcal antigen testing is performed on all CSF specimens submitted for fungal culture, if specimen volume allows
Provision of relevant, clinical information is important to ensure a clinically relevant result Always provide/report: • clinical history - symptoms, signs, duration • antimicrobial history • travel history • Is the patient immunocompromised: - chronic infections - steroid and other immunosuppressive therapy - post-transplant - hematological or other malignancy
Handling and Storage:
*Store at Room Temperature DO NOT refrigerate
Handling/Storage Comments:
Transport STAT to the collecting-site laboratory to ensure specimen is received within 15 minutes of collection.
The specimen must be received at the testing laboratory within 1 hour of collection - laboratory staff - comment internally on any specimens showing obvious hemolysis, lipemia or turbidity
Serum specimens: if transport is delayed, store at 2-8ºC for up to 72 hours
All CSF specimens received with a request for Cryptococcal antigen are cultured for fungus
If further information is required, contact the Microbiologist-on-call. Calgary/South, Phone: 1-800-661-9876
Note: Testing is performed once in a 7-day period regardless of previous patient results. Cryptococcal antigen has been validated at the Calgary Diagnostic & Scientific Centre (DSC). It is US FDA approved but not Health Canada approved. Results should be interpreted in the clinical context